Myeloid-Derived Suppressor Cells and Costimulatory Molecules in Children With Allergic Rhinitis-Reference-Cited by-同舟云学术

Myeloid-Derived Suppressor Cells and Costimulatory Molecules in Children With Allergic Rhinitis

Published:2018-11-18 Issue:2 Volume:128 Page:128-134
ISSN:0003-4894
Container-title:Annals of Otology, Rhinology & Laryngology
language:en
Short-container-title:Ann Otol Rhinol Laryngol

Author:

Zahran Asmaa M.¹,Saad Khaled²^ORCID,Elsayh Khalid I.²,Abdelmoghny Abobakr³,Aboul-Khair Mohamed Diab⁴,Sobhy Ali⁵,Abdel-Raheem Yasser F²,El-Asheer Osama M.²,El-Houfey Amira A.⁶⁷,Alblihed Mohamd A.⁸,Al-Neami Ibrahim⁹

Affiliation:

1. Clinical Pathology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt

2. Pediatric Department, Faculty of Medicine, Assiut University, Assiut, Egypt

3. Department of ENT, Faculty of Medicine, Al-Azhar University, Assiut, Egypt

4. Department of Pediatrics, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

5. Department of Clinical Pathology, Faculty of Medicine, Alazhar University, Assiut, Egypt

6. Department of Community Health Nursing, Faculty of Nursing, Assiut University, Egypt

7. Department of Community Health Nursing, Sabia University College, Jazan University, Kingdom of Saudi Arabia

8. Department of Medical Biochemistry, School of Medicine, Taif University, Taif, Kingdom of Saudi Arabia

9. Director of Training and Scholarship Administration, MOH, Gizan, Kingdom of Saudi Arabia

Abstract

Objectives: The aim of this study is to assess the level of myeloid-derived suppressor cells (MDSCs) and the expression of costimulatory molecules CD80 and CD86 on monocytes and their ligands (CD28) on T-lymphocytes in children with allergic rhinitis (AR). Methods: The study included 60 children with AR and 50 controls. Flow cytometry was performed to analyze MDSCs and the expression of costimulatory molecules CD80 and CD86 on monocytes and their ligands (CD28) on T-lymphocytes. Results: The percentages of total and monocytic MDSCs and the expression of costimulatory molecule CD86 on monocytes were significantly higher in children with AR than in healthy controls. In addition, the expressions of CD28 on CD4+ and CD8+ were significantly elevated in AR patients. Conclusion: The present study demonstrated that the percentages of MDSCs were significantly elevated in AR children. Moreover, the expressions of CD28 on CD4+ and CD8+ were significantly higher in children with AR.

Publisher

SAGE Publications

Subject

General Medicine,Otorhinolaryngology

Link

http://journals.sagepub.com/doi/pdf/10.1177/0003489418812902

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