Laryngeal Clefts

Author:

Lim Timothy A.1,Spanier Suzanne S.2,Kohut Robert I.1

Affiliation:

1. Irvine, California

2. Gainesville, Florida

Abstract

The histopathologic findings in a case of laryngeal cleft studied by serial sectioning, and a literature review of this clinical entity are presented. The primary micropathologic findings include a cleft deformity of the posterior cricoid lamina, and alterations in muscle differentiation involving the interarytenoid and posterior cricoarytenoid muscles. Possible embryogenic mechanisms are discussed. The clinical picture is characterized by signs and symptoms of aspiration with airway obstruction, and definitive diagnosis is achieved by endoscopic examination. Treatment consists of surgical repair, although some patients with type 1 laryngeal clefts may be managed on a conservative trial. The need for uniform classification of laryngeal clefts in future reporting is emphasized.

Publisher

SAGE Publications

Subject

General Medicine,Otorhinolaryngology

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2. Disruption of BMP4 signaling is associated with laryngeal birth defects in a mouse model;Developmental Biology;2023-08

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