Audioprofile Surfaces-Reference-Cited by-同舟云学术

Audioprofile Surfaces

Published:2015-11-03 Issue:5 Volume:125 Page:361-368
ISSN:0003-4894
Container-title:Annals of Otology, Rhinology & Laryngology
language:en
Short-container-title:Ann Otol Rhinol Laryngol

Author:

Taylor Kyle R.¹²,Booth Kevin T.³,Azaiez Hela³,Sloan Christina M.⁴,Kolbe Diana L.³,Glanz Emily N.¹²,Shearer A. Eliot³,DeLuca Adam P.⁵,Anand V. Nikhil²,Hildebrand Michael S.³,Simpson Allen C.³,Eppsteiner Robert W.³,Scheetz Todd E.¹²⁵,Braun Terry A.¹²,Huygen Patrick L. M.⁶,Smith Richard J. H.³⁴,Casavant Thomas L.¹²⁵

Affiliation:

1. Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, USA

2. Center for Bioinformatics and Computational Biology, University of Iowa, Iowa City, Iowa, USA

3. Department of Otolaryngology, Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA

4. Department of Molecular Physiology and Biophysics, University of Iowa Carver, Iowa City, Iowa, USA

5. Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USA

6. Department of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

Abstract

Objective: To present audiometric data in 3 dimensions by considering age as an addition dimension. Methods: Audioprofile surfaces (APSs) were fitted to a set of audiograms by plotting each measurement of an audiogram as an independent point in 3 dimensions with the x, y, and z axes representing frequency, hearing loss in dB, and age, respectively. Results: Using the Java-based APS viewer as a standalone application, APSs were pre-computed for 34 loci. By selecting APSs for the appropriate genetic locus, a clinician can compare this APS-generated average surface to a specific patient’s audiogram. Conclusion: Audioprofile surfaces provide an easily interpreted visual representation of a person’s hearing acuity relative to others with the same genetic cause of hearing loss. Audioprofile surfaces will support the generation and testing of sophisticated hypotheses to further refine our understanding of the biology of hearing.

Publisher

SAGE Publications

Subject

General Medicine,Otorhinolaryngology

Link

http://journals.sagepub.com/doi/pdf/10.1177/0003489415614863

Reference11 articles.

1. THE IOWA PITCH RANGE AUDIOMETER AND ITS USES

2. Autosomal Dominant Low-Frequency Hearing Impairment (DFNA6/14)

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