Assessment of Immunocompetent Cells in Patients with Head and Neck Squamous Cell Carcinoma

Author:

Dawson Douglas E.1,Vetto R. Mark2,Everts Edwin C.2,Burger Denis R.2

Affiliation:

1. Iowa City, Iowa

2. Portland, Oregon

Abstract

Patients with squamous cell carcinoma of the head and neck have impaired T cell function and poor tumor-specific responsiveness. Disproportionate levels of circulating immunocompetent cells could be one reason for this diminished immunity. In this study, a panel of monoclonal antibodies and flow cytofluorometry were used to define the relative proportions of selected immune cell populations. We detected a deficiency of the interleukin-2-producing subset of T helper-inducer cells (TH 5.2 +) in these patients. Our data showed no significant differences in circulating levels of total T cells, T cell subsets, B cells, monocytes, or natural killer cells when compared to age, alcohol- and tobacco-use matched controls.

Publisher

SAGE Publications

Subject

General Medicine,Otorhinolaryngology

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