Vitamin a Deficiency Causes Metaplasia in Vocal Fold Epithelium: A Rat Study-Reference-Cited by-同舟云学术

Vitamin a Deficiency Causes Metaplasia in Vocal Fold Epithelium: A Rat Study

Published:2008-02 Issue:2 Volume:117 Page:153-158
ISSN:0003-4894
Container-title:Annals of Otology, Rhinology & Laryngology
language:en
Short-container-title:Ann Otol Rhinol Laryngol

Author:

Tateya Ichiro¹²,Tateya Tomoko³²,Surles Rebecca Lynn⁴,Kanehira Kazunori⁵,Tanumihardjo Sherry⁴,Bless Diane M.²

Affiliation:

1. Department of Otolaryngology, Kyoto Katsura Hospital, Kyoto, Japan

2. Division of Otolaryngology–Head and Neck Surgery, Department of Surgery, University of Wisconsin-Madison, Madison, Wisconsin.

3. Department of Otolaryngology–Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan

4. Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, Wisconsin.

5. Department of Pathology, University of Wisconsin-Madison, Madison, Wisconsin.

Abstract

Objectives The roles of vitamin A in the vocal fold epithelium are not well documented, although vitamin A has been used as a conservative treatment for laryngeal leukoplakia. The purpose of this study was to analyze the roles of vitamin A in vocal fold epithelial differentiation. Methods Vitamin A–deficient (VAD) rats were generated, and the abnormality of their vocal fold epithelium was examined by hematoxylin and eosin staining and immunohistochemical analysis for keratin 10 and transglutaminase (TGase) 1. Results The VAD experimental rats exhibited orthokeratosis of the vocal fold epithelium. Keratin 10 and TGase 1 were up-regulated in the epithelium of the VAD rats. Conclusions It is suggested that vitamin A suppresses TGase 1 expression in normal vocal folds to inhibit keratinization, and that the TGase 1 up-regulation caused by vitamin A deficiency may be related to the formation of metaplasia in the laryngeal epithelium.

Publisher

SAGE Publications

Subject

General Medicine,Otorhinolaryngology

Link

http://journals.sagepub.com/doi/pdf/10.1177/000348940811700214

Reference19 articles.

1. Regulation of Differentiation of the Tracheobronchial Epithelium

2. Expression of Retinoic Acid Nuclear Receptors and Tissue Transglutaminase Is Altered in Various Tissues of Rats Fed a Vitamin A-Deficient Diet

3. Regulation of mucous differentiation and mucin gene expression in the tracheobronchial epithelium

4. Differentiation-dependent regulation of retinal dehydrogenase gene expression in the trachea

5. Long-term follow-up of larynx leukoplakia under treatment with retinyl palmitate

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Accuracy of narrow‐band imaging for diagnosing malignant transformation of vocal cord leukoplakia: A systematic review and meta‐analysis;Laryngoscope Investigative Otolaryngology;2023-03-29

2. Vocal Folds Leukoplakia: The Efficacy of Vitamin A in the Initial Treatment;International Archives of Otorhinolaryngology;2022-11-10

3. Dynamics of vitamin A uptake, storage, and utilization in vocal fold mucosa;Molecular Metabolism;2020-10

4. Developing a Model of Vitamin A Deficiency in a Hibernating Mammal, the 13-Lined Ground Squirrel (Ictidomys tridecemlineatus);Comparative Medicine;2018-06-01

5. Anatomo-Physiology of the Glottis and Neoglottic Region;Injection Laryngoplasty;2015