Rat Model for a Vascularized Laryngeal Allograft

Author:

Strome Scott1,Sloman-Moll Erik2,Wu Justin3,Samonte Bernadette R.3,Strome Marshall3

Affiliation:

1. Ann Arbor, Michigan

2. Washington, DC

3. Boston, Massachusetts

Abstract

A new rat model was developed to reexamine the potential for laryngeal transplantation. The final anatomic derivation evolved from two earlier developmental phases. The first model had only a single arterial anastomosis; the second had an end-to-end arterial anastomosis with an end-to-end arteriovenous shunt. The final product employed an end-to-side arterial shunt and an end-to-side arteriovenous shunt for revascularization. The allografts were sited in tandem with the intact recipient larynges and were not innervated. A total of 16 animals were studied in phase 3; 2 died and the remaining 14 had a 64% arterial patency at intervals of 1 to 14 days. Our purpose is to detail the relevant technical considerations of this new model and compare it with historical controls.

Publisher

SAGE Publications

Subject

General Medicine,Otorhinolaryngology

Cited by 47 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Greffe laryngée après laryngectomie totale chez l’homme : analyse SWiM;Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale;2024-04

2. Laryngeal graft after total laryngectomy in humans: A SWiM analysis;European Annals of Otorhinolaryngology, Head and Neck Diseases;2023-12

3. A Heterotopic Mouse Model for Studying Laryngeal Transplantation;Journal of Visualized Experiments;2023-01-13

4. A New Animal Model of Laryngeal Transplantation;Journal of Clinical Medicine;2022-10-30

5. Perfusion-Decellularized Larynx as a Natural 3D Scaffold in a Rabbit Model;ORL;2021-11-04

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3