Histopathologic and Experimental Models for Sensory and Neural Deafness

Author:

Spector Gershon J.1

Affiliation:

1. St. Louis, Missouri

Abstract

Six selected cases with neonatal and fetal cochlear pathology are presented. Those denoting cochlear sepsis are: H. influenza purulent labyrinthitis, cytomegalovirus endolabyrinthitis, and aseptic meningitis and labyrinthitis. Those denoting cochlear neural aplasia are Goldenhar's syndrome, left-sided cardiac hypoplasia with partial basal turn neural aplasia, and cerebral cortical and ventricular hemorrhage with modiolar extension. These findings are compared to the fluorocitrate ototoxicity model for neural deafness in the guinea pig. This study suggests hypotheses for viral trophism in the inner ear and neural degeneration of the cochlea as mechanisms for sensorineural deafness.

Publisher

SAGE Publications

Subject

General Medicine,Otorhinolaryngology

Reference41 articles.

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2. Understanding Hereditary Nerve Deafness

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