Three Times Daily or 8-Hourly-Reference-Cited by-同舟云学术

Three Times Daily or 8-Hourly

Published:1986-01 Issue:1 Volume:79 Page:15-16
ISSN:0141-0768
Container-title:Journal of the Royal Society of Medicine
language:en
Short-container-title:J R Soc Med

Author:

Nigam R¹,Loveday B J²,Grainger S L³,Maxton D G³

Affiliation:

1. University of Newcastle upon Tyne

2. Guy's Hospital, London SE1

3. St Thomas' Hospital, London SE1

Abstract

The timing of drug ingestion over 24 hours was assessed in 58 outpatients taking drugs three times daily. The mean time between 1st and 2nd dose was 5.7 hours, 2nd and 3rd 6.1 hours and between 3rd and 1st of the next day 12.2 hours. Based on a simulation of hydralazine pharmacokinetics, such irregular administration would increase peak levels by 10% and decrease trough levels by 64% compared with regular 8-hourly doses.

Publisher

SAGE Publications

Subject

General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/014107688607900105

Reference5 articles.

1. Clinical Pharmacokinetics of Hydrallazine

2. Plasma levels and negative chronotropic effect of metoprolol following single doses of a conventional and sustained-release formulation

3. Drug Defaulting in a General Practice

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