1. Leeds Institute of Health Sciences, University of Leeds, Leeds LS2 9JT, UK
2. Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford OX2 6GG, UK
3. Institute for Research in Operative Medicine, Witten/Herdecke University, Alfred-Herrhausen-Straûe 50, 58448 Witten, Germany
4. Centre for Health Sciences, Oklahoma State University, Tulsa 74107, USA
5. Department of Paediatrics, University of Toronto, Toronto M5G 1X8, Canada