Ultrastructural Localization of IgA Deposits in Adult Linear IgA Disease

Author:

Leonard J N1,Ring Nicola1,Haffenden G P1,Fry Lionel1

Affiliation:

1. Departments of Dermatology and Histopathology St Mary's Hospital, London W2 1NY

Abstract

Two cases of adult linear IgA disease are reported. They demonstrate the two sites of deposition of IgA at an ultrastructural level: sub-basal lamina and lamina lucida. This finding supports the view that there are subgroups of this disease. Clinical presentation and histological appearance of lesional skin are misleading, and the immunofluorescent appearance is unhelpful in predicting the ultrastructural localization of the IgA deposit.

Publisher

SAGE Publications

Subject

General Medicine

Reference20 articles.

1. BeanS F, FureyN L, ChorzelskiT P, JablonskaS (1979) In: Immunopathology of the Skin. Ed. BeutnerE H John Wiley, New York; pp 320–327

2. ChorzelskiT P, JablonskaS, BeutnerE H (1979) In: Immunopathology of the Skin. Ed. BeutnerE H John Wiley, New York; pp 316–320

3. Dermatitis Herpetiformis

4. The small intestine in dermatitis herpetiformis

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