Desloratadine: A Nonsedating Antihistamine

Author:

Limon Lynn1,Kockler Denise R2

Affiliation:

1. Lynn Limon PharmD, Drug Information Specialist, Department of Pharmacy Services, Virginia Commonwealth University Health System, Medical College of Virginia Hospitals and Physicians, Richmond, VA

2. Denise R Kockler PharmD, Director, Drug Information Service, Department of Pharmacy Services, Virginia Commonwealth University Health System, Medical College of Virginia Hospitals and Physicians

Abstract

OBJECTIVE: To review information on desloratadine, a nonsedating antihistamine. DATA SOURCES: An English-language MEDLINE search was conducted (1966–July 2002). References of identified articles were subsequently reviewed for additional data. Schering Corporation provided unpublished information. STUDY SELECTION/DATA EXTRACTION: Articles and abstracts pertaining to desloratadine were considered for inclusion, with emphasis on randomized, placebo-controlled, double-blind trials. DATA SYNTHESIS: Desloratadine is approved for the treatment of symptoms associated with seasonal allergic rhinitis (SAR), perennial allergic rhinitis (PAR), and chronic idiopathic urticaria (CIU) in patients aged ≥12 years. In placebo-controlled trials, desloratadine demonstrated superior efficacy as a once-daily treatment of SAR, PAR, and CIU. Data suggest that desloratadine has antiinflammatory and decongestant activity. CONCLUSIONS: Desloratadine appears to be a “me-too” agent, with no major differences compared with other second-generation antihistamines.

Publisher

SAGE Publications

Subject

Pharmacology (medical)

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