Severe Hypersensitivity Reaction upon Rechallenge with Trimethoprim-Sulfamethoxazole in a Patient with AIDS-Reference-Cited by-同舟云学术

Severe Hypersensitivity Reaction upon Rechallenge with Trimethoprim-Sulfamethoxazole in a Patient with AIDS

Published:1988-01 Issue:1 Volume:22 Page:43-45
ISSN:0012-6578
Container-title:Drug Intelligence & Clinical Pharmacy
language:en
Short-container-title:Drug Intelligence & Clinical Pharmacy

Author:

Arnold Patricia A.¹,Guglielmo B. Joseph²,Hollander Harry³

Affiliation:

1. Department of Pharmacy Services, Good Samaritan Medical Center, 1111 E. McDowell Rd., Phoenix, AZ 85006

2. Division of Clinical Pharmacy, School of Pharmacy

3. Department of Medicine, University of California Medical Center, San Francisco, CA.

Abstract

A patient with acquired immunodeficiency syndrome (AIDS) developed rash, fever, neutropenia, and elevated liver function tests during an initial course of trimethoprim-sulfamethoxazole (TMP-SMX) therapy. Upon reexposure to the drug, the patient experienced a severe anaphylactoid reaction associated with pulmonary edema and rhabdomyolysis. Reactions associated with TMP-SMX rechallenge in this patient population have been previously reported but have not been associated with this degree of severity. TMP-SMX therapy should be instituted with extreme caution in patients with AIDS who have demonstrated a prior hypersensitivity reaction to the drug.

Publisher

SAGE Publications

Subject

Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics

Link

http://journals.sagepub.com/doi/pdf/10.1177/106002808802200110

Reference11 articles.

1. Trimethoprim-Sulfamethoxazole for the Treatment of Pneumocystis carinii Pneumonia

2. COMPLICATIONS OF CO-TRIMOXAZOLE IN TREATMENT OF AIDS-ASSOCIATED PNEUMOCYSTIS CARINII PNEUMONIA IN HOMOSEXUAL MEN

3. Cutaneous Reaction to Trimethoprim-Sulfamethoxazole in Patients with AIDS and Kaposi's Sarcoma

4. The Treatment of Pneumocystis carinii Pneumonia in the Acquired Immunodeficiency Syndrome

5. Adverse Reactions to Trimethoprim-Sulfamethoxazole in Patients with the Acquired Immunodeficiency Syndrome

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