Abstract
Isotretinoin is remarkably effective in the treatment of severe cystic acne, however, many complications have been observed during treatment and new toxic effects have been reported. Hypertriglyceridemia associated with decreases in high density lipoprotein (HDL) cholesterol has occurred in 25 percent of patients and requires monitoring during treatment. Painful erosions with granulation tissue recently have been reported in patients with severe acne. Other complications have included corneal opacities, pseudotumor cerebri, hypercalcemia, photosensitivity reactions, abnormal liver function tests, and skeletal hyperostosis. Isotretinoin is teratogenic and should be avoided during pregnancy. With the increasing acceptance and use of isotretinoin for cystic acne, as well as related disorders (inflammatory papulopustular acne with scarring, gram-negative folliculitis, and acne rosacea), a reevaluation of isotretinoin aimed at reducing complications is in order. Patient selection criteria and guidelines directed at reducing these complications are presented.
Subject
Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics
Cited by
8 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Psychiatric and Developmental Effects of Isotretinoin (Retinoid) Treatment for Acne Vulgaris;Current Therapeutic Research;2019
2. The role of aquaporin-1 in idiopathic and drug-induced intracranial hypertension;Medical Hypotheses;2013-12
3. Évaluation du potentiel photosensibilisant du gluconate de zinc;Annales de Dermatologie et de Vénéréologie;2005-03
4. Isotretinoin;Vorträge und Dia-Klinik der 16. Fortbildungswoche 1998 Fortbildungswoche für Praktische Dermatologie und Venerologie e.V. c/o Klinik und Poliklinik für Dermatologie und Allergologie Ludwig-Maximilians-Universität München in Verbindung mit dem Berufsverband der Deutschen Dermatologen e.V.;1999
5. How Safe Is Oral Isotretinoin?;Dermatology;1997