Author:
Hartshorn Edward A.,Lomaestro Ben M.,Bailie George R.
Abstract
The quinolone class of antibiotics is enjoying a recent resurgence in interest and use due to the development of improved compounds. Norfloxacin, ciprofloxacin, and, most recently, ofloxacin have been marketed. Enoxacin and other agents are in various stages of investigation. These newer compounds are often used for indications not successfully treated by the original quinolones, or in some cases, not optimally treated with any previously available oral antibiotic. A potential problem with the increasing use of quinolone-type antibiotics for systemic illness is the chelation and inactivation of these compounds by several cations. One outcome of these potential interactions is a possible reduction in bioavailability and effectiveness of quinolone compounds. A review of the literature on quinolone-cation interactions, in vivo and in vitro significance, and recommendations to avoid potential problems are provided.
Subject
Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics
Cited by
88 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Electrochemical and DFT insights into 2-amino-4-(4-hydroxy-3-methoxyphenyl)-7-methyl-4H-chromene-3-carbonitrile: an innovative strategy for antibacterial activity and corrosion protection of carbon steel;RSC Advances;2024
2. Sulfonamides, quinolones, antiseptics, and disinfectants;Medicinal Chemistry of Chemotherapeutic Agents;2023
3. Enteral Medication for the Tube‐Fed Patient: Making This Route Safe and Effective;Nutrition in Clinical Practice;2020-12-29
4. Synthesis, characterization, antimicrobial activity, 3D‐QSAR, DFT, and molecular docking of some ciprofloxacin derivatives and their copper(II) complexes;Applied Organometallic Chemistry;2020-10-10
5. Spectroscopic characterization, thermogravimetric and antimicrobial studies of some new metal complexes derived from4‐(4‐Isopropyl phenyl)‐2‐oxo‐6‐phenyl 1,2‐dihyropyridine‐3‐carbonitrile (L);Applied Organometallic Chemistry;2019-11-25