Drug Interactions Involving Immunologic Agents Part I. Vaccine–Vaccine, Vaccine–Immunoglobulin, and Vaccine–Drug Interactions

Abstract

Information about immunologic drug interactions is needed by pharmacists to make rational drug-use decisions. Previously, reports of interactions involving vaccines, immune globulins, and immunodiagnostic reagents were widely dispersed. In this two-part review article, over 50 individual and categorical interactions are described, as are dozens of vaccine–vaccine and vaccine–immunoglobulin combinations for which interactions have been demonstrated not to occur. Vaccine–vaccine, vaccine–immunoglobulin, and vaccine–drug interactions are reviewed in this first part. Vigilance by all pharmacists is needed to detect previously unreported immunologic drug interactions and to further assess known interactions.