Fixed Drug Eruption of the Penis Due to Hydroxyzine Hydrochloride-Reference-Cited by-同舟云学术

Fixed Drug Eruption of the Penis Due to Hydroxyzine Hydrochloride

Published:1997-03 Issue:3 Volume:31 Page:327-329
ISSN:1060-0280
Container-title:Annals of Pharmacotherapy
language:en
Short-container-title:Ann Pharmacother

Author:

Cohen Herman Avner¹,Barzilai Asher²,Matalon Andre³,Harel Liora⁴,Gross Samuel⁵

Affiliation:

1. Pediatric Ambulatory Center, Department of Family Medicine, Sackler School of Medicine, Tel Aviv University, Petach Tikvah, Israel

2. Infectious Disease Unit, Chaim Sheba, Tel Hashomer, Israel

3. Department of Family Medicine, Sackler School of Medicine, Tel Aviv University

4. Department of Pediatrics “C,” Schneider Chil-dren's Medical Center of Israel, Sackler School of Medicine, Tel Aviv University

5. Pediatric Ambulatory Center, Department of Family Medicine, Sackler School of Medicine, Tel Aviv University

Abstract

Objective To report four cases of fixed drug eruption induced by hydroxyzine hydrochloride (Otarex, Teva, Israel). Case Summary Four children with restlessness who were treated with hydroxyzine hydrochloride developed fixed drug eruption of the penis. Drug discontinuation was followed by complete resolution of the skin eruption. Rechallenge resulted in the same drug rash. Macrophage migration inhibiting factor (MIF) assay with hydroxyzine hydrochloride was positive. Discussion The pathogenesis of fixed drug eruption and the role of macrophage MTF assay in diagnosis is discussed. Conclusions A fixed drug eruption induced by hydroxyzine hydrochloride is possible, but is a rare phenomenon.

Publisher

SAGE Publications

Subject

Pharmacology (medical)

Link

http://journals.sagepub.com/doi/pdf/10.1177/106002809703100311

Reference9 articles.

1. CURRENT CAUSES OF FIXED DRUG ERUPTIONS

2. Macrophage Migration Inhibition Factor (MIF) in Drug Eruption

3. Fixed Drug Eruption

4. DEMONSTRATION OF INTERCELLULAR IMMUNOFLUORESCENCE AND EPIDERMAL HYSTERESIS IN BULLOUS FIXED DRUG ERUPTION DUE TO PHENOLPHTHALEIN

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