Comparative Studies of the Influence of Elevated Serum Lipid Levels on the Pharmacokinetics of Diazepam in rabbits and humans

Abstract

The influence of elevated serum lipids on the pharmacokinetics of diazepam was investigated in rabbits. The results obtained were then compared with similar results of experiments carried out in humans. The changes in the pharmacokinetics of diazepam due to elevated lipid levels have similar characteristics in animals and humans. Elevated serum lipid levels cause a decrease in diazepam serum concentration.