Nonrheumatologic Uses of NSAIDS

Author:

Evens Ronald P.1

Affiliation:

1. Department of Clinical Pharmacy, College of Pharmacy, The University of Tennessee Center for the Health Sciences, Memphis, TN 38163.

Abstract

Nonsteroidal anti inflammatory drugs (NSAIDs) have several salient indications outside of their role in rheumatology. Two major uses are treatment of dysmenorrhea and patent ductus arteriosus. Other established roles encompass treatment of fever, pain, Banter's syndrome, and thromboembolic disorders. Animal and human studies are being done on the use of NSAIDs in cancer, diabetes, psoriasis, and shock, just to name a few investigative areas. NSAIDs are not a panacea nor are they wonder drugs to be used indiscriminately. When these drugs first were marketed in the 1970s, they were considered safe agents with little toxicity. However, the side-effect profile of the NSAIDs has been, and continues to be, better identified over the past few years and warrants judicious use of these drugs. Their adverse effects potentially include gastric distress (possibly hemorrhage), allergic urticaria or bronchospasm in asthma patients, azotemia, arrested labor, skin reactions, and water retention. NSAIDs are relatively safe agents with a growing list of new indications. Future clinical evaluation holds the key to the balance between their emerging toxicities and indications.

Publisher

SAGE Publications

Subject

Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics

Cited by 6 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Non-steroidal anti-inflammatory drugs (NSAIDs);Meyler's Side Effects of Drugs;2016

2. NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs);Meyler's Side Effects of Analgesics and Anti-inflammatory Drugs;2010

3. The efficacy and safety of aceclofenac versus placebo and naproxen in women with primary dysmenorrhoea;European Journal of Obstetrics & Gynecology and Reproductive Biology;2006-12

4. Non-steroidal anti-inflammatory drugs (NSAIDs);Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions;2006

5. Anti-inflammatory analgesics and drugs used in rheumatoid arthritis and gout;Side Effects of Drugs Annual;1985

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