Verapamil-Associated Stevens-Johnson Syndrome

Author:

Lin Anne Y.F.1,Baker Brian A.2

Affiliation:

1. College of Pharmacy and Allied Health Professions, St. John's University, Grand Central and Utopia Pkwys., Jamaica, NY 11439

2. Albany College of Pharmacy, Albany, NY

Abstract

Stevens-Johnson syndrome (SJS) is a complication infrequently associated with the use of calcium-channel blocking agents. A 59-year-old woman developed symptoms typical of SJS approximately ten days following the initiation of sustained-release verapamil for hypertension management. Symptoms consisted of a generalized red macular rash associated with swelling of the face, tongue, lips, and mouth as well as a fever of 40 °C. Resolution of symptoms began approximately four days after verapamil discontinuation. Rechallenge with verapamil was not peformed. Although SJS appears to be a rare adverse effect of this drug, the potential complications warrant the inclusion of SJS in the differential diagnosis of patients presenting with malaise, fever, rash, and a history of verapamil ingestion.

Publisher

SAGE Publications

Subject

Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics

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