Author:
Pucino Frank,Baumgart Peggy J.,Strommen Gordon L.,Silbergleit Inger-Lise,Forbes Dave,Hoag Stephen G.,Beck Carol L.,Tedros Nancy M.
Abstract
The need for a therapeutic drug monitoring service was evaluated in a 150-bed long-term care facility. Thirty blood samples from 28 residents (mean age 87.9 years) were assayed to determine trough drug concentrations. All subjects were examined to determine pharmacodynamic effect. Pharmacokinetic consultations were written for serum drug concentrations outside accepted ranges. Fifty percent (15 of 30) of serum drug levels measured were subtherapeutic; the remaining levels were in the normal therapeutic range. Based on this sample data, it could be concluded that a minimum of 32 percent and as many as 68 percent of serum drug levels would be subtherapeutic following drug analysis in similar nursing home populations. Of 12 consultations, recommendations for seven (58 percent) were accepted by the subject's primary care physicians. Four of the consultations (33 percent) resulted in dosage modifications. These results support the need for further study.
Subject
Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics
Reference17 articles.
1. Snedecor GW, Cochran WG. Statistical methods. 7th ed. Ames, IA: Iowa State University Press, 1980: 107–34.
2. Fluorescence polarization immunoassay. II. Analyzer for rapid, precise measurement of fluorescence polarization with use of disposable cuvettes.
3. Li TM, Burd JF. Determination of theophylline concentration in human serum using the substrate-labeled fluorescent immunoassay (abstract). Proceedings of the Eleventh International Congress of Biochemistry. New York: Pergamon Press, 1979: 522.
4. Determination of Therapeutic and Toxic Serum Digoxin Concentrations by Radioimmunoassay
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献