Author:
Madan P. L.,Minisci Marie
Abstract
Seventeen commercial brands of enteric-coated sodium salicylate tablets have been evaluated for their ability to resist release of their active ingredient in acidic gastric environment. The results show that although the tablets meet the official enteric-coated tablet disintegration test requirement, the coating on at least ten brands failed to provide the necessary protection. simulated gastric fluid, the fluid was replaced with simulated intestinal fluid (without enzymes).4 A disk was added to each tube and the apparatus was operated until the tablets showed evidence of softening, crackling, or complete disintegration.
Subject
Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics
Reference9 articles.
1. Enteric-coated aspirin overdose and gastric perforation.
2. Gastric Irritation and Bleeding after Drug Administration
3. The United States Pharmacopeia, XIX rev., Mack Publishing Co., Easton, Pa. (1975) p. 765.
4. National Formulary, 14th ed., American Pharmaceutical Association, Washington, D. C. (1975) p. 901.
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