Congenital Heart Defects in Nigerian Children: Preliminary Data From the National Pediatric Cardiac Registry

Author:

Ekure Ekanem N.1ORCID,Bode-Thomas Fidelia2,Sadoh Wilson E.3,Orogade Adeola A.4,Otaigbe Barbara E.5,Ujunwa Fortune6,Sani Usman M.7,Asani Mustafa8,Animasahun Adeola B.9,Ogunkunle Oluwatoyin O.10,

Affiliation:

1. Department of Pediatrics, College of Medicine, University of Lagos, Lagos, Nigeria

2. Department of Pediatrics, University of Jos, Jos, Nigeria

3. Department of Pediatrics, University of Benin, Benin City, Nigeria

4. Department of Pediatrics, Ahmadu Bello University, Zaria, Nigeria

5. Department of Pediatrics, University of Port Harcourt, Port Harcourt, Nigeria

6. Department of Pediatrics, University of Nigeria, Nsukka, Nigeria

7. Department of Pediatrics, Usmanu Danfodiyo University, Sokoto, Nigeria

8. Department of Pediatrics, Bayero University, Kano, Nigeria

9. Department of Pediatrics and Child Health, Lagos State University, Ojo, Lagos, Nigeria

10. Department of Pediatrics, University of Ibadan, Ibadan, Nigeria

Abstract

Background: Congenital heart defects (CHDs) are common birth defects with significant impact on morbidity and mortality. We aimed to compare regional patterns of CHDs in Nigeria using a registry-based approach. Methods: Children with echocardiography-confirmed CHDs at 17 medical centers across the country were enrolled in a pilot National Pediatric Cardiac Registry from January to December 2014. Results: A total of 1,296 children (52.9% male; median age 0.9 years) with CHDs were enrolled. Patients enrolled in Northern Nigeria constituted 34.6% of the study population and were older compared to those enrolled from Southern Nigeria (2.9 ± 3.6 vs 2.4 ± 3.5 years; P = .02). Ventricular septal defects were significantly more prevalent in the North (37.4%) compared with the South (18.5%; P < .0001), while severe CHDs were more prevalent in the South ( P = .004). Of the 208 (16.0%) children who received corrective cardiac intervention, only 43 (20.7%) of them had the intervention done in country. More patients in the South received intervention compared to the North (19.02% vs 10.5%; P < .0001). Conclusion: This is the first prospective, registry-based, multicenter study of CHDs in Nigerian children. We demonstrate important differences between the Northern and the Southern geographical regions of the country in terms of age at diagnosis, type, and severity of lesion as well as access to cardiac surgery. The findings demonstrate the utility of a national CHDs registry for understanding clinical epidemiology of CHDs in low- and middle-income countries and its potential to serve as a basis for research and planning.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,General Medicine,Pediatrics, Perinatology and Child Health,Surgery

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