TGF-β Signaling and itsFunctionalSignificance inRegulating theFate ofCranialNeuralCrestCells-Reference-Cited by-同舟云学术

TGF-β Signaling and itsFunctionalSignificance inRegulating theFate ofCranialNeuralCrestCells

Published:2003-03 Issue:2 Volume:14 Page:78-88
ISSN:1045-4411
Container-title:Critical Reviews in Oral Biology & Medicine
language:en
Short-container-title:Critical Reviews in Oral Biology & Medicine

Author:

Chai Y.¹,Ito Y.¹,Han J.¹

Affiliation:

1. Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033;

Abstract

Members of the transforming growth factor-β (TGF-β) superfamily regulate cell proliferation, differentiation, and apoptosis, and control the development and maintenance of most tissues. TGF-β signal is transmitted through the phosphorylation of Smad proteins by TGF-β receptor serine/threonine kinase. During craniofacial development, TGF-β may regulate the fate specification of cranial neural crest cells. These cells are multipotent progenitors and capable of producing diverse cell types upon differentiation. Here we summarize evidence that TGF-β ligands and their signaling intermediates have significant roles in patterning and specification of cranial neural crest cells. The biological function of TGF-β is carried out through the regulation of transcriptional factors during embryogenesis.

Publisher

SAGE Publications

Subject

General Dentistry,Otorhinolaryngology

Link

http://journals.sagepub.com/doi/pdf/10.1177/154411130301400202

Reference146 articles.

1. TβRI Phosphorylation of Smad2 on Ser465 and Ser467 Is Required for Smad2-Smad4 Complex Formation and Signaling

2. Akimenko MA, Johnson SL, Westerfield M, Ekker M (1995). Differential induction of four msx homeobox genes during fin development and regeneration in zebrafish. Development 2:347–357.

3. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

4. Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors

5. Antisense attenuation ofWnt-1 andWnt-3a expression in whole embryo culture reveals roles for these genes in craniofacial, spinal cord, and cardiac morphogenesis

Cited by 63 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Genetic Analysis and Functional Assessment of aTGFBR2Variant in Micrognathia and Cleft Palate;2024-04-11

2. Intravitreal injection of FGF and TGF-β inhibitors disrupts cranial cartilage development;Differentiation;2023-09

3. TGF-β and BMP Signaling Pathways in Skeletal Dysplasia with Short and Tall Stature;Annual Review of Genomics and Human Genetics;2023-08-25

4. Circadian clock—A promising scientific target in oral science;Frontiers in Physiology;2022-11-16

5. Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis;Journal of Visualized Experiments;2022-04-01