Signal Transducers and Activators of Transcription: Insights into the Molecular Basis of Oral Cancer-Reference-Cited by-同舟云学术

Signal Transducers and Activators of Transcription: Insights into the Molecular Basis of Oral Cancer

Published:2004-09 Issue:5 Volume:15 Page:298-307
ISSN:1045-4411
Container-title:Critical Reviews in Oral Biology & Medicine
language:en
Short-container-title:Critical Reviews in Oral Biology & Medicine

Author:

Siavash H.¹²³,Nikitakis N.G.¹²³,Sauk J.J.¹²³

Affiliation:

1. Department of Biomedical Sciences and

2. Department of Diagnostic Sciences and Pathology, University of Maryland, Dental School, 666 West Baltimore Street, Room 4-C-02, Baltimore, MD 21201; and

3. Greenebaum Cancer Center, University of Maryland, Baltimore, MD 21201;

Abstract

Recent efforts on developing more direct and effective targets for cancer therapy have revolved around a family of transcription factors known as STATs (signal transducers and activators of transcription). STAT proteins are latent cytoplasmic transcription factors that become activated in response to extracellular signaling proteins. STAT proteins have been convincingly reported to possess oncogenic properties in a plethora of human cancers, including oral and oropharyngeal cancer. Signal transduction pathways mediated by these oncogenic transcription factors and their regulation in oral cancer are the focus of this review.

Publisher

SAGE Publications

Subject

General Dentistry,Otorhinolaryngology

Link

http://journals.sagepub.com/doi/pdf/10.1177/154411130401500505

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