Targeted Drug Delivery in Cancer Therapy-Reference-Cited by-同舟云学术

Targeted Drug Delivery in Cancer Therapy

Published:2005-08 Issue:4 Volume:4 Page:363-374
ISSN:1533-0346
Container-title:Technology in Cancer Research & Treatment
language:en
Short-container-title:Technol Cancer Res Treat

Author:

Vasir Jaspreet K.¹,Labhasetwar Vinod¹²

Affiliation:

1. Department of Pharmaceutical Sciences College of Pharmacy 986025 Nebraska Medical Center Omaha, NE 68198-6025, USA

2. Department of Biochemistry and Molecular Biology Nebraska Medical Center Omaha, NE 68198-6025, USA

Abstract

Chemotherapy has been the main modality of treatment for cancer patients; however, its success rate remains low, primarily due to limited accessibility of drugs to the tumor tissue, their intolerable toxicity, development of multi-drug resistance, and the dynamic heterogeneous biology of the growing tumors. Better understanding of tumor biology in recent years and new targeted drug delivery approaches that are being explored using different nanosystems and bioconjugates provide optimism in developing successful cancer therapy. This article reviews the possibilities and challenges for targeted drug delivery in cancer therapy.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology

Link

http://journals.sagepub.com/doi/pdf/10.1177/153303460500400405

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