Spectral Polarization Imaging of Human Prostate Cancer Tissue Using a Near-infrared Receptor-targeted Contrast Agent-Reference-Cited by-同舟云学术

Spectral Polarization Imaging of Human Prostate Cancer Tissue Using a Near-infrared Receptor-targeted Contrast Agent

Published:2005-08 Issue:4 Volume:4 Page:429-436
ISSN:1533-0346
Container-title:Technology in Cancer Research & Treatment
language:en
Short-container-title:Technol Cancer Res Treat

Author:

Pu Y.¹,Wang W. B.²,Tang G. C.²,Zeng F.²,Achilefu S.³,Vitenson J. H.⁴,Sawczuk I.⁵,Peters S.⁶,Lombardo J. M.⁶,Alfano R. R.²

Affiliation:

1. Department of Electrical Engineering

2. Department of Physics The City College of the City Univ. of NY Convent Avenue at 138th Street New York, NY 10031

3. Washington University School of Medicine 4525 Scott Avenue St. Louis. Missouri 63110

4. Department of Urology

5. Department of Urology Hackensack University Medical Center Adjunct Professor of Urology College of Physicians and Surgeons Columbia University Professor of Surgery (Urology) UMDNJ Newark Medical School

6. Department of Pathology Hackensack University Medical Center 30 Prospect Avenue Hackensack, NJ 07601

Abstract

The Cypate-Bombesin Peptide Analogue Conjugate (Cybesin) was used as a prostate tumor receptor-targeted contrast agent. The absorption and fluorescence spectra of Cybesin were measured and shown to exist in the NIR tissue “optical window”. The spectral polarization imaging of Cybesin-stained prostate cancerous and normal tissues shows that prostate cancerous tissue takes-up more Cybesin than that of prostate normal tissue, making Cybesin a potential marker of prostate cancer.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology

Link

http://journals.sagepub.com/doi/pdf/10.1177/153303460500400410

Reference15 articles.

1. Optical properties of normal and diseased human breast tissues in the visible and near infrared

2. Near Infrared Spectroscopy and Imaging to Probe Differences in Water Content in Normal and Cancer Human Prostate Tissues

3. Novel fluorescent contrast agents for optical imaging of in vivo tumors based on a receptor-targeted dye-peptide conjugate platform

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