Prognostic Value of C-met Expression in Cholangiocarcinoma

Author:

Mao Zhi-Yuan1,Zhu Guang-Qing1,Ren Li2,Guo Xiao-Chuan3,Su Dan3,Bai Li3

Affiliation:

1. Department of Oncology, Air Force General Hospital of PLA, Beijing, China

2. Department of Pathology, Air Force General Hospital of PLA, Beijing, China

3. Department of Oncology, Chinese PLA General Hospital, Beijing, China

Abstract

Aim: To explore the relationship of clinicopathological features and the proteins of C-met expression in the prognosis of cholangiocarcinoma. Methods: Clinical data and the completed follow-up information of patients with cholangiocarcinoma who underwent cholangiocarcinoma operation from January 2004 to December 2010 were analyzed retrospectively. The relationship of clinicopathological features and C-met in the prognosis of the patients was analyzed. Results: Patients with high expression of C-met had significantly shorter overall survival than those with low expression of C-met, the difference being statistically significant ( P = .003). Patients with high C-met expression had significantly shorter disease-free survival time than those with low expression of C-met, the difference being statistically significant ( P = .009). By COX multivariate analysis, high C-met expression in tumor tissues was an independent risk factor in predicting overall survival and disease-free survival for patients with cholangiocarcinoma ( P = .038, .048, relative risk = 1.390, 1.427). Conclusion: Patients with high C-met expression in cancer tissues had shorter disease-free survival and overall survival. High expression of C-met is an independent risk factor for overall survival and disease-free survival.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology

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