New Light on the Brain: The Role of Photosensitizing Agents and Laser Light in the Management of Invasive Intracranial Tumors

Author:

Eljamel M. Sam1

Affiliation:

1. Department of Neurosurgery, South Block, Level 6, Ninewells Hospital & Medical School, Dundee DD1 9SY, UK

Abstract

Invasive intracranial tumors, particularly malignant gliomas, are very difficult to eradicate surgically and carry a dismal prognosis. The vast majority relapse locally indicating that their cure is dependent on radical and complete local excision. However, their ability to invade and hide among normal brain tissue, our inability to visualize and detect them, the low tolerance of brain tissue to ionizing radiation and the presence of the blood brain barrier are the main causes of our failure to eradicate them. Photodynamic detection with 100% specificity and more than 80% sensitivity offers an excellent chance of visualizing camouflaged tumor nests. Also, photodynamic therapy offers a very good chance of targeted destruction of the remaining tumor cells safely following surgical excision and may double the survival of patients harboring these awful tumors. More work needs to be done to refine this promising technology to exploit it to its full potential.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology

Cited by 36 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. A Review on Future Prospects of Photosensitizers in Photodynamic Therapy;International Journal of Newgen Research in Pharmacy & Healthcare;2024-06-30

2. Current Photodynamic Therapy for Glioma Treatment: An Update;Biomedicines;2024-02-06

3. Photodynamic therapy during second surgery for recurrent gliomas improves survival;Photodiagnosis and Photodynamic Therapy;2022-06

4. Photodynamic therapy for cancer treatment;Photophysics and Nanophysics in Therapeutics;2022

5. Photodynamic therapy in the treatment of brain tumours. A feasibility study;Photodiagnosis and Photodynamic Therapy;2015-09

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