MD-2 binds to bacterial lipopolysaccharide-Reference-Cited by-同舟云学术

MD-2 binds to bacterial lipopolysaccharide

Published:2000-12 Issue:6 Volume:6 Page:489-491
ISSN:0968-0519
Container-title:Journal of Endotoxin Research
language:en
Short-container-title:Journal of Endotoxin Research

Author:

Viriyakosol S.¹,Kirkland T.N.²,Soldau K.³,Tobias P.S.³

Affiliation:

1. Department of Pathology and Medicine, Department of Veterans Affairs Medical Center, University of California San Diego, San Diego, California, USA

2. Department of Pathology and Medicine, Department of Veterans Affairs Medical Center, University of California San Diego, San Diego, California, USA.

3. Department of Immunology, The Scripps Research Institute, La Jolla, California, USA

Abstract

Many LPS binding proteins have been described, but the exact nature of the LPS receptors that signal cells remains unclear. MD-2 is a molecule that is found in association with Toll-like receptor 4, which has been shown to be a receptor for LPS. We have produced human MD-2 in baculovirus and tested it for LPS binding. MD-2 binds the lipid A region of LPS without the need for LPS binding protein. These data suggest that MD-2 may be binding LPS as part of the TLR4 receptor complex.

Publisher

SAGE Publications

Subject

Infectious Diseases,Cell Biology,Molecular Biology,Immunology,Microbiology

Link

http://journals.sagepub.com/doi/pdf/10.1177/09680519000060060201

Reference8 articles.

1. CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

2. Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

3. Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction

4. MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

5. Structure-Function Analysis of CD14 as a Soluble Receptor for Lipopolysaccharide

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