Essential role of MD-2 in B-cell responses to lipopolysaccharide and Toll-like receptor 4 distribution-Reference-Cited by-同舟云学术

Essential role of MD-2 in B-cell responses to lipopolysaccharide and Toll-like receptor 4 distribution

Published:2002-12 Issue:6 Volume:8 Page:449-452
ISSN:0968-0519
Container-title:Journal of Endotoxin Research
language:en
Short-container-title:Journal of Endotoxin Research

Author:

Miyake Kensuke¹,Nagai Yoshinori²,Akashi Sachiko²,Nagafuku Masakazu³,Ogata Masato⁴,Kosugi Atsushi³

Affiliation:

1. Division of Infectious Genetics, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan, -tokyo.ac.jp, CREST, Japan Science and Technology Corporation, Tokyo, Japan

2. Division of Infectious Genetics, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan, CREST, Japan Science and Technology Corporation, Tokyo, Japan

3. CREST, Japan Science and Technology Corporation, Tokyo, Japan, School of Allied Health Sciences, Faculty of Medicine, Osaka University Medical School, Osaka, Japan

4. Department of Oncogenesis, Osaka University Medical School, Osaka, Japan

Abstract

Toll-like receptor 4 (TLR4) mediates lipopolysaccharide (LPS) signaling in a variety of cell types. MD-2 is associated with the extracellular domain of TLR4 and augments TLR4-dependent LPS responses in vitro. Moreover, mice lacking MD-2 (MD-2— /—) do not respond to LPS, survive endotoxin shock, and are susceptible to Salmonella typhimurium infection. Here, we further show that B cells lacking MD-2 do not up-regulate CD23 in response to LPS. TLR4 predominantly resides in the Golgi apparatus without MD-2. MD-2 is essential for LPS responses in vivo.

Publisher

SAGE Publications

Subject

Infectious Diseases,Cell Biology,Molecular Biology,Immunology,Microbiology

Link

http://journals.sagepub.com/doi/pdf/10.1177/09680519020080061401

Reference19 articles.

1. Receptor-Dependent Mechanisms of Cell Stimulation by Bacterial Endotoxin

2. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

3. A family of human receptors structurally related to Drosophila Toll

4. Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

5. Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (Tlr4)

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