Development and Validation of a Clinical Frailty Index for the World Trade Center General Responder Cohort-Reference-Cited by-同舟云学术

Development and Validation of a Clinical Frailty Index for the World Trade Center General Responder Cohort

Published:2021-03-12 Issue:7-8 Volume:33 Page:531-544
ISSN:0898-2643
Container-title:Journal of Aging and Health
language:en
Short-container-title:J Aging Health

Author:

Bello Ghalib A.¹^ORCID,Ornstein Katherine A.²,Lucchini Roberto G.¹³⁴,Hung William W.²⁵,Ko Fred C.²⁵,Colicino Elena⁶,Taioli Emanuela⁷⁸⁹,Crane Michael A.¹⁰,Todd Andrew C.¹

Affiliation:

1. Department of Environmental Medicine and Public Health, World Trade Center Health Program General Responder Data Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA

2. Brookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA

3. Florida International University, School of Public Health, Miami, FL, USA

4. University of Brescia, Brescia, Italy

5. James J. Peters VA Medical Center, New York, NY, USA

6. Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA

7. Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

8. Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA

9. Department of Thoracic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA

10. Department of Environmental Medicine and Public Health, World Trade Center Health Program Clinical Center of Excellence at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Abstract

Objectives: To develop and validate a clinical frailty index to characterize aging among responders to the 9/11 World Trade Center (WTC) attacks. Methods: This study was conducted on health monitoring data on a sample of 6197 responders. A clinical frailty index, WTC FI-Clinical, was developed according to the cumulative deficit model of frailty. The validity of the resulting index was assessed using all-cause mortality as an endpoint. Its association with various cohort characteristics was evaluated. Results: The sample’s median age was 51 years. Thirty items were selected for inclusion in the index. It showed a strong correlation with age, as well as significant adjusted associations with mortality, 9/11 exposure severity, sex, race, pre-9/11 occupation, education, and smoking status. Discussion: The WTC FI-Clinical highlights effects of certain risk factors on aging within the 9/11 responder cohort. It will serve as a useful instrument for monitoring and tracking frailty within this cohort.

Funder

Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health

Publisher

SAGE Publications

Subject

Geriatrics and Gerontology,Community and Home Care,Gerontology

Link

http://journals.sagepub.com/doi/pdf/10.1177/0898264321997675

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