Pre- and Early Peri-menopausal Physical Function and Risk of Cardiovascular Events: The Study of Women’s Health Across the Nation-Reference-Cited by-同舟云学术

Pre- and Early Peri-menopausal Physical Function and Risk of Cardiovascular Events: The Study of Women’s Health Across the Nation

Published:2022-10-17 Issue:5-6 Volume:35 Page:383-391
ISSN:0898-2643
Container-title:Journal of Aging and Health
language:en
Short-container-title:J Aging Health

Author:

Lange-Maia Brittney S.¹²^ORCID,El Khoudary Samar R.³,Crandall Carolyn J.⁴,Zhang Yanyu⁵,Karvonen-Gutierrez Carrie A.⁶,Gabriel Kelley Pettee⁷,Appelhans Bradley M.²,Strotmeyer Elsa S.³,Ylitalo Kelly R.⁸^ORCID,Karavolos Kelly²,Kravitz Howard M.²⁹,Dugan Sheila A.¹⁰,Janssen Imke²

Affiliation:

1. Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA

2. Department of Family and Preventive Medicine, Rush University Medical Center, Chicago, IL, USA

3. Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA

4. Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA

5. Rush Bioinformatics and Biostatics Core, Rush University Medical Center, Chicago, IL, USA

6. Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA

7. Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA

8. Department of Public Health, Baylor University, Waco, TX, USA

9. Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA

10. Department of Physical Medicine and Rehabilitation, Rush University Medical Center, Chicago, IL, USA

Abstract

Objectives To determine whether physical function (PF) before menopause is related to cardiovascular disease (CVD) risk. Methods Participants were N = 2950 pre-/early peri-menopausal women (median age 46, (25th–75th percentile: 43–48 years). Physical function was assessed at baseline using the Physical Function subscale of the SF-36 and scores were trichotomized (no, some, or substantial limitations). Clinical CVD events were ascertained at annual/biennial clinical assessments through the 15th follow-up visit. Risk of CVD was determined with Cox proportional hazards models. Results: Women were followed for a median of 19.1 years, during which 220 women had a CVD event. In fully adjusted models, women with substantial limitations at baseline had higher CVD risk compared to women with no limitations (hazards ratio [HR] = 1.55, 95% confidence interval [CI]: 1.12–2.33). Discussion: Substantial PF limitations in pre- and early peri-menopausal women are associated with higher risk of clinical CVD events, consistent with literature in older adults.

Funder

National Institute on Aging

National Institute of Nursing Research

Publisher

SAGE Publications

Subject

Geriatrics and Gerontology,Community and Home Care,Gerontology

Link

http://journals.sagepub.com/doi/pdf/10.1177/08982643221133580

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