Associations Between Body Mass Index and Cognitive Change in the ACTIVE Study: Variations by Race and Social Determinants of Health-Reference-Cited by-同舟云学术

Associations Between Body Mass Index and Cognitive Change in the ACTIVE Study: Variations by Race and Social Determinants of Health

Published:2023-10 Issue:9_suppl Volume:35 Page:59S-73S
ISSN:0898-2643
Container-title:Journal of Aging and Health
language:en
Short-container-title:J Aging Health

Author:

Aiken-Morgan Adrienne T.¹^ORCID,McDonough Ian M.²,Parisi Jeanine M.³^ORCID,Clay Olivio J.⁴^ORCID,Thomas Kelsey R.⁵⁶^ORCID,Rotblatt Lindsay J.⁷,Thorpe Roland J.⁸^ORCID,Marsiske Michael⁷

Affiliation:

1. Department of Psychiatry, University of North Carolina – Chapel Hill School of Medicine, Chapel Hill, NC, USA

2. Department of Psychology, University of Alabama, Tuscaloosa, AL, USA

3. Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

4. Department of Psychology, University of Alabama, Birmingham, AL, USA

5. Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA

6. Department of Psychiatry, University of California San Diego, La Jolla, CA, USA

7. Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA

8. Johns Hopkins Alzheimer’s Disease Resource Center for Minority Aging Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

Abstract

Objectives: The current study examines relationships between Body Mass Index (BMI) and cognitive performance and change in processing speed, memory, and reasoning, while accounting for variations by race and the influence of social determinants of health. Methods: Secondary data analysis of the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) study, which included participants who self-identified as African American or Black ( n = 728) and White ( n = 2028). Latent growth curve modeling was used to assess study aims. Results: Increases in BMI were associated with less cognitive decline over 10 years across each cognition domain. Race moderation effects were noted for speed and memory. Relationships between BMI and cognitive trajectories were mediated by economic stability for speed and reasoning. Discussion: Overall, these findings are consistent with the “obesity paradox.” Further research is needed to elucidate patterns of results by race.

Funder

Aiken-Morgan

Vanderbilt Diabetes Research and Training Center

North Carolina Diabetes Research Center

UAB Alzheimer’s Disease Research Center

Publisher

SAGE Publications

Subject

Geriatrics and Gerontology,Community and Home Care,Gerontology

Link

http://journals.sagepub.com/doi/pdf/10.1177/08982643221109645

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