Effects of Cognitive Training on Alzheimer’s Disease and Related Dementias: The Moderating Role of Social Determinants of Health-Reference-Cited by-同舟云学术

Effects of Cognitive Training on Alzheimer’s Disease and Related Dementias: The Moderating Role of Social Determinants of Health

Published:2023-10 Issue:9_suppl Volume:35 Page:40S-50S
ISSN:0898-2643
Container-title:Journal of Aging and Health
language:en
Short-container-title:J Aging Health

Author:

Rebok George W.¹²³^ORCID,Gellert Andrew⁴,Coe Norma B.⁵,Clay Olivio J.⁶⁷^ORCID,Wallace Gail¹²^ORCID,Parisi Jeanine M.¹²^ORCID,Aiken-Morgan Adrienne T.⁸^ORCID,Crowe Michael⁶⁷,Ball Karlene⁶⁷,Thorpe Roland J.²³⁹^ORCID,Marsiske Michael¹⁰,Zahodne Laura B.¹¹,Felix Cynthia¹²,Willis Sherry L.¹³

Affiliation:

1. Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

2. Johns Hopkins Alzheimer’s Disease Resource Center for Minority Aging Research, Johns Hopkins University, Baltimore, MD, USA

3. Johns Hopkins Center on Aging and Health, Johns Hopkins University, Baltimore, MD, USA

4. TIAA Institute, New York, NY, USA

5. Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

6. Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA

7. Deep South Resource Center for Minority Aging Research, University of Alabama at Birmingham, Birmingham, AL, USA

8. Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA

9. Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

10. Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA

11. Department of Psychology, University of Michigan, Ann Arbor, MI, USA

12. Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA

13. Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA

Abstract

Objective: We examined whether social determinants of health (SDoH) are associated with Alzheimer’s disease and related dementias (ADRD) risk and the effects of cognitive training over a 20-year follow-up period. Methods: Data were obtained from 1605 participants in ACTIVE. SDoH measures were created using baseline data at the individual and neighborhood level. Incident ADRD was defined using administrative claims data (1999–2019). Cause-specific hazard models estimated associations between SDoH and claims-based diagnosed ADRD. Results: Higher scores on neighborhood and built environment were associated with lower ADRD risk. Trained participants obtained a greater degree of protection from ADRD when they had higher scores for SDoH domains associated with health care and education access. However, there were fewer significant SDoH moderation effects on cognitive training than expected. Discussion: Future work should continue to explore culturally tailored cognitive training interventions to reduce ADRD risk associated with SDoH that disproportionately affects racially diverse aging populations.

Funder

National Institutes of Health

School of Medicine, Indiana University

Johns Hopkins University

New England Research Institutes

Pennsylvania State University

University of Alabama at Birmingham

University of Florida

University of Alabama at Birmingham Alzheimer’s Disease Research Center

Johns Hopkins Alzheimer’s Disease Resource Center for Minority Aging Research

Publisher

SAGE Publications