1. Warwick Medical School, University of Warwick, Coventry, CV4 7HL, UK
2. Cardiff and Vale Orthopaedic Centre, University Hospital Llandough, Penarth, UK
3. Department of Trauma and Orthopaedics, North Bristol NHS Trust, Southmead Hospital, Bristol, UK
4. National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol, Bristol, UK
5. Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, UK