A Rare Case of Breast fat-Forming Solitary Fibrous Tumor With Molecular Confirmation

Abstract

Solitary fibrous tumor (SFT) is an uncommon fibroblastic neoplasm which may arise in a wide range of anatomic location and can occur across all ages. Fat-forming SFT is a rare morphological variant of SFT. Primary breast fat-forming SFT is exquisitely rare. Here, we report a case in a 51-year-old Chinese woman with a palpable painless mass in the left breast. A color Doppler ultrasound scan examination demonstrated a 3.4-cm oval, well-circumscribed, hypoechoic solid mass with several peripheral and internal color flow signals. Magnetic resonance imaging (MRI) showed a focal lobulated solid nodular lesion displaying geographical enhancement but no architectural distortion. Subsequently, she underwent a left breast lumpectomy. In histopathologic examination, there was a well-circumscribed, cellular spindle cell tumor consisting of short fascicles of bland, fusiform, ovoid to spindle cells disposed in a patternless architecture around branching vascular spaces within a fibrous stroma with wispy collagen. Cells revealed mild nuclear atypia. Mitotic figures were up to 4/10 high-power fields (HPFs) in the hot spot. Mature adipocytes intermixed with spindle cells were also observed. The tumor cells were diffusely positive for CD34 and STAT6. Some S100-expressing adipocytes co-expressed STAT6. Next-generation sequencing (NGS) revealed the presence of the NAB2exon6::STAT6exon2 fusion. The histological, immunohistochemical (IHC) and molecular examinations confirmed the diagnosis of fat-forming SFT. Post-excision, the patient showed no signs of tumor recurrence or metastasis in a 7-month follow-up. Here, we describe a rare case of a fat-forming SFT involving the breast and highlight the comprehensive pathological evaluation and necessary ancillary testing.