A Case of Mediastinal Carcinosarcoma With Beta-HCG Production and KRAS Mutation

Author:

Shaker Nada1ORCID,Amadi Chiemezie C.2,Welliver Meng3,Otterson Gregory A.4,Liebner David A.4,Shilo Konstantin1ORCID

Affiliation:

1. Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA

2. Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, USA

3. Division of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH, USA

4. Division of Medical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH, USA

Abstract

Carcinosarcomas of mediastinum are rare and only few well-documented cases are available in the literature. We report a detailed description of mediastinal carcinosarcoma with unique clinical manifestations and immunohistochemical and molecular profiles. A 44-year-old female with an enlarging anterior mediastinal mass was found to have a positive pregnancy test. Thoracoscopic biopsy revealed that the mass represented a carcinosarcoma with adenocarcinoma and chondrosarcoma components. The tumor focally expressed beta-HCG by immunohistochemistry and had KRAS G12A missense mutation by next generation sequencing. The case documents a rare presentation of carcinosarcoma within the mediastinum with uncommon paraneoplastic syndrome and genetic profile. Awareness of these unusual clinical and pathological manifestations of the tumor will help in reaching correct diagnosis and proper management of such patients.

Publisher

SAGE Publications

Subject

Pathology and Forensic Medicine,Surgery,Anatomy

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1. Antineoplastics;Reactions Weekly;2024-08-17

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