Secretory Carcinoma of Breast Demonstrates Nuclear or Cytoplasmic Expression in p63 Immunohistochemistry-Reference-Cited by-同舟云学术

Secretory Carcinoma of Breast Demonstrates Nuclear or Cytoplasmic Expression in p63 Immunohistochemistry

Published:2012-04-04 Issue:4 Volume:20 Page:367-372
ISSN:1066-8969
Container-title:International Journal of Surgical Pathology
language:en
Short-container-title:Int J Surg Pathol

Author:

Choi Junjeong¹,Kim Dokyung²,Koo Ja Seung³

Affiliation:

1. Yonsei University Wonju College of Medicine, Wonju, South Korea

2. Ajou University Medical Center, Suwon, South Korea

3. Yonsei University College of Medicine, Seoul, South Korea.

Abstract

The aim of this study was to evaluate the pattern of p63 expression and its implication in secretory carcinoma of the breast. Immunohistochemical staining for p63, p53, MDM2, and smooth muscle actin was performed in 7 cases of secretory carcinomas. Nuclear expression of p63 was observed in 3 cases, whereas staining against cytoplasmic and intraluminal secretory material were observed in 4 cases. p53 was expressed in 3 cases and MDM2 in 2 cases. The loss of myoepithelial cells was confirmed by immunohistochemical stain for smooth muscle actin in invasive secretory carcinomas. The pattern of expression of p63 in secretory carcinoma of the breast was revealed in nuclei or cytoplasm/secretory materials.

Publisher

SAGE Publications

Subject

Pathology and Forensic Medicine,Surgery,Anatomy

Link

http://journals.sagepub.com/doi/pdf/10.1177/1066896912440506

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