Kikuchi Disease After SARS-CoV-2 Vaccination: A Case Report With Immunohistochemical Analyses-Reference-Cited by-同舟云学术

Kikuchi Disease After SARS-CoV-2 Vaccination: A Case Report With Immunohistochemical Analyses

Published:2023-11-19 Issue: Volume: Page:
ISSN:1066-8969
Container-title:International Journal of Surgical Pathology
language:en
Short-container-title:Int J Surg Pathol

Author:

Hamamoto Yuichiro¹²^ORCID,Kawamura Michihiro³,Mori Hideo⁴,Uchida Hiroki³,Hiramatsu Kazuhiro³,Katori Chiaki³,Asai Hinako³,Kawasaki Hiroko⁵,Minamino Taishi⁶,Hashimoto Michiko⁵,Nakatsuka Shin-ichi⁷,Yoshida Kyotaro³

Affiliation:

1. Department of Diagnostic Pathology, Kinki Central Hospital, Itami, Hyogo, Japan

2. Department of Pathology, Osaka University Graduate School of Medicine, Suita, Japan

3. Department of Clinical Laboratory, Kinki Central Hospital, Itami, Hyogo, Japan

4. Department of Diagnostic Pathology, Osaka Habikino Medical Center, Osaka, Japan

5. Department of Otorhinolaryngology, Kinki Central Hospital, Itami, Hyogo, Japan

6. Department of Otorhinolaryngology-Head and Neck Surgery, Osaka General Medical Center, Osaka, Japan

7. Department of Pathology, Yao Tokushukai General Hospital, Osaka, Japan

Abstract

SARS-CoV-2 vaccines have been administered in many countries after the COVID-19 pandemic. Lymphadenopathy is a side effect of SARS-CoV-2 vaccine. We report a rare example of Kikuchi disease in the cervical lymph nodes after SARS-CoV-2 vaccination. A 41-year-old man complained of a swollen neck and fever 9 days after the first dose of SARS-CoV-2 mRNA-1273 vaccine. Computed tomography revealed enlarged cervical lymph nodes. Fine needle aspiration and resection were performed, and the clinicopathological diagnosis was consistent with Kikuchi disease. Histologically, the resected lymph nodes lost their polarity, and many histiocytes were aggregated with karyorrhectic nuclear debris and apoptosis. SARS-CoV-2 positive cells were small lymphocytes detected by immunohistochemistry. This is the first report that demonstrated SARS-CoV-2 expression in Kikuchi disease post-SARS-CoV-2 vaccination.

Publisher

SAGE Publications

Subject

Pathology and Forensic Medicine,Surgery,Anatomy

Link

http://journals.sagepub.com/doi/pdf/10.1177/10668969231212428

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