BRAF T1799A Mutation Occurring in a Case of Malignant Struma Ovarii-Reference-Cited by-同舟云学术

BRAF T1799A Mutation Occurring in a Case of Malignant Struma Ovarii

Published:2007-04 Issue:2 Volume:15 Page:116-120
ISSN:1066-8969
Container-title:International Journal of Surgical Pathology
language:en
Short-container-title:Int J Surg Pathol

Author:

Flavin Richard¹,Smyth Paul¹,Crotty Paul²,Finn Stephen¹,Cahill Susanne¹,Denning Karen¹,Jinghuan Li ¹,O'Regan Esther¹,O'Leary John³,Sheils Orla⁴

Affiliation:

1. Departments of Histopathology, St. James's Hospital, Trinity College, Dublin, Ireland

2. Tallaght Hospital, Trinity College, Dublin, Ireland

3. The Coombe Women's Hospital and Trinity College, Dublin, Ireland

4. Departments of Histopathology, St. James's Hospital, Trinity College, Dublin, Ireland,

Abstract

Struma ovarii is an extremely rare tumor that occasionally undergoes malignant transformation. Because struma ovarii is composed of thyroid tissue, it is conceivable that the pathogenetic events involved in thyroid follicular transformation may take place also in struma ovarii. The authors describe a case of a classical variant of papillary thyroid carcinoma arising in a struma ovarii of a 22-year-old female. The tumor was heterozygous for BRAF T1799A mutation. No ret/ PTC-1 or ret/PTC-3 rearrangements were detected. This finding would suggest that malignant struma ovarii is similar histologically and genetically to primary papillary thyroid carcinoma.

Publisher

SAGE Publications

Subject

Pathology and Forensic Medicine,Surgery,Anatomy

Link

http://journals.sagepub.com/doi/pdf/10.1177/1066896906299131

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