Anterior Mediastinal Neuroblastoma Associated with Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Morphologic, Immunohistochemical, and Genetic Case Report and Review of the Literature-Reference-Cited by-同舟云学术

Anterior Mediastinal Neuroblastoma Associated with Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Morphologic, Immunohistochemical, and Genetic Case Report and Review of the Literature

Published:2022-02-21 Issue:6 Volume:30 Page:689-696
ISSN:1066-8969
Container-title:International Journal of Surgical Pathology
language:en
Short-container-title:Int J Surg Pathol

Author:

Kennedy Gregory T.¹^ORCID,Sande Christopher M.¹,Surrey Lea F.²^ORCID,Azari Feredun S.¹,Deshpande Charuhas¹,Singhal Sunil¹

Affiliation:

1. University of Pennsylvania School of Medicine, Philadelphia, PA, USA

2. Children’s Hospital of Philadelphia, Philadelphia, PA, USA

Abstract

We report a mediastinal neuroblastoma in an octogenarian with paraneoplastic syndrome of inappropriate antidiuretic hormone secretion (SIADH). Neuroblastomas are very rare tumors in adults, with thoracic or mediastinal locations being especially uncommon. These neoplasms have been occasionally associated with the SIADH. Given the rarity of incidence and paucity of diagnostic and outcomes data, the significance of standard neuroblastoma prognostic characteristics is unclear, and no treatment paradigms exist for these patients. Further studies are needed to inform future clinical guidelines.

Funder

American Philosophical Society

Society of Thoracic Surgeons

Foundation for the National Institutes of Health

Publisher

SAGE Publications

Subject

Pathology and Forensic Medicine,Surgery,Anatomy

Link

http://journals.sagepub.com/doi/pdf/10.1177/10668969221080061

Reference18 articles.

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