The Co-Existence of Micronodular Thymoma and Lymphoma: A Clinicopathological and Immunohistochemical Study of Two Cases

Abstract

Two cases with the co-existence of micronodular thymoma and lymphoma are presented. The patients are two female patients 54 and 60 years of age who presented with symptoms of chest pain, general malaise, cough, and dyspnea. Diagnostic imaging demonstrated the presence of an anterior mediastinal mass. Initial biopsy was interpreted as an epithelial neoplasm compatible with thymoma. Surgical resection took place demonstrating the presence of micronodular thymoma in both cases. In addition, in both cases the lymphoid proliferation infiltrated surrounding adipose tissue. However, in one case the lymphoid proliferation was composed of atypical lymphocytes with irregular nuclei and increase mitotic activity positive for CD3 and TDT, while in the second case, the lymphoid proliferation was composed of more mature lymphocytes with a monocytoid appearance and positive for CD20. Both of these cases represent an unusual association and one that must be kept in the differential diagnosis especially in cases of micronodular thymoma.