Diffuse Large B-Cell Lymphoma With Striking Intrasinusoidal Pseudoglandular Growth Pattern as a Diagnostic Dilemma Mimicking Metastatic Poorly Differentiated Pancreatic Adenocarcinoma in an Intraabdominal Lymph Node-Reference-Cited by-同舟云学术

Diffuse Large B-Cell Lymphoma With Striking Intrasinusoidal Pseudoglandular Growth Pattern as a Diagnostic Dilemma Mimicking Metastatic Poorly Differentiated Pancreatic Adenocarcinoma in an Intraabdominal Lymph Node

Published:2018-11-04 Issue:2 Volume:27 Page:181-184
ISSN:1066-8969
Container-title:International Journal of Surgical Pathology
language:en
Short-container-title:Int J Surg Pathol

Author:

Yau David¹^ORCID,Aron Manju¹,Siddiqi Imran N.¹

Affiliation:

1. University of Southern California, Los Angeles, CA, USA

Abstract

We report an unusual intrasinusoidal growth pattern of an intraabdominal diffuse large B-cell lymphoma both clinically and histologically mimicking a metastatic adenocarcinoma. A 66-year-old woman presented with a high-grade distal biliary stricture with multiple enlarged abdominal lymph nodes. Frozen section at the time of pancreatoduodenectomy (“Whipple”) demonstrated cohesive nests of large atypical cells within a totally effaced lymph node presenting a diagnostic challenge. Immunohistochemistry proved this to be a diffuse large B-cell lymphoma extensively involving the sinusoids.

Publisher

SAGE Publications

Subject

Pathology and Forensic Medicine,Surgery,Anatomy

Link

http://journals.sagepub.com/doi/pdf/10.1177/1066896918810866

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