Upper Urothelial Tract Extraosseous Bone Formation: An Unexpected Finding and Differential Diagnostic Considerations-Reference-Cited by-同舟云学术

Upper Urothelial Tract Extraosseous Bone Formation: An Unexpected Finding and Differential Diagnostic Considerations

Published:2024-01-31 Issue:6 Volume:32 Page:1222-1225
ISSN:1066-8969
Container-title:International Journal of Surgical Pathology
language:en
Short-container-title:Int J Surg Pathol

Author:

Potterveld Susan K.¹^ORCID,Wang Nancy²,Sangoi Ankur R.¹^ORCID

Affiliation:

1. Department of Pathology, Stanford Medical Center, Stanford, CA, USA

2. Department of Urology, Palo Alto Medical Foundation, Mountain View, CA, USA

Abstract

Extraosseous bone formation of the upper urothelial tract is an unusual phenomenon with limited documentation in the uropathology literature, reported in only 2 clinical series of patients undergoing percutaneous nephrolithotomy for the management of renal stones. While speculations regarding the pathogenesis of this occurrence have been published, heterotopic ossification is still poorly understood. We report the finding of extraosseous bone formation in the renal pelvis of a 30-year-old male patient with a history of kidney stones. Histologic sections of the ureter and renal pelvis showed submucosal nodules of woven bone. Ancillary fluorescence in-situ hybridization studies were negative for MDM2 amplification and USP6 rearrangement.

Publisher

SAGE Publications

Link

https://journals.sagepub.com/doi/pdf/10.1177/10668969231221755

Reference11 articles.

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4. Heterotopic Ossification Leading to Ureteral Obstruction Resulting in Nephrectomy