Regressed Cutaneous Malignant Melanoma Mimicking Lymphoma: A Potential Diagnostic Pitfall-Reference-Cited by-同舟云学术

Regressed Cutaneous Malignant Melanoma Mimicking Lymphoma: A Potential Diagnostic Pitfall

Published:2005-07 Issue:3 Volume:13 Page:281-284
ISSN:1066-8969
Container-title:International Journal of Surgical Pathology
language:en
Short-container-title:Int J Surg Pathol

Author:

Menasce L. P.¹,Shanks J. H.¹,Howarth V. S.²,Banerjee S. S.¹

Affiliation:

1. Department of Pathology, Christie Hospital NHS Trust, Manchester

2. Stepping Hill Hospital NHS Foundation Trust, Stockport, UK

Abstract

We report 2 cases of partially regressed malignant melanoma in which the brisk lymphocytic response closely resembled mycosis fungoides in 1 case and nodular sclerosing Hodgkin lymphoma in the other. Striking epidermotropism was present in both cases. The lymphocytes were predominantly of T8 cytotoxic subtype, and oligoclonal T-cell expansion was detected in 1 of the cases. The scanty residual melanoma cells were highlighted with HMB45 and S100 protein. We highlight the features of regression in melanoma that may lead to an erroneous diagnosis of lymphoma and discuss the finding of oligoclonal T-cell expansion in regressed melanocytic lesions.

Publisher

SAGE Publications

Subject

Pathology and Forensic Medicine,Surgery,Anatomy

Link

http://journals.sagepub.com/doi/pdf/10.1177/106689690501300310

Reference5 articles.

1. The significance of inflammation and regression in melanoma

2. Observation of cells resembling sternberg-reed cells in conditions other than Hodgkin's disease

3. Analysis of T cell receptor variability in tumor-infiltrating lymphocytes from a human regressive melanoma. Evidence for in situ T cell clonal expansion.

4. Presence and localization of T-cell subsets in relation to melanocyte differentiation antigen expression and tumour regression as assessed by immunohistochemistry and molecular analysis of microdissected T cells

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Proliferative Clonal T-Cell Infiltrate Mimicking a Cutaneous T-Cell Lymphoma Arising in Active Regression of Melanoma;The American Journal of Dermatopathology;2021-07-20

2. Is it mycosis fungoides? A comprehensive guide to reaching the diagnosis and avoiding common pitfalls;Annals of Diagnostic Pathology;2020-08

3. Nonlymphoid Tumors Mimicking Lymphoma;Cutaneous Hematopathology;2014

4. Cutaneous T-cell lymphoma occurring with a melanocytic proliferation, masquerading as a nonhealing ulcer with reactive changes;Journal of Cutaneous Pathology;2010-11-18

5. Inflammatory melanoma: a potential diagnostic pitfall;Pathology;2010-10