Dedifferentiated Ovarian Carcinoma with ARID1A and ARID1B Mutations: A Clinicopathological Report and Literature Review-Reference-Cited by-同舟云学术

Dedifferentiated Ovarian Carcinoma with ARID1A and ARID1B Mutations: A Clinicopathological Report and Literature Review

Published:2023-02-27 Issue:8 Volume:31 Page:1526-1531
ISSN:1066-8969
Container-title:International Journal of Surgical Pathology
language:en
Short-container-title:Int J Surg Pathol

Author:

Kamal Maria¹^ORCID,Atwi Doaa¹^ORCID,Pang Hui²,Li Shibo²,Hassell Lewis¹

Affiliation:

1. Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

2. Genetics Lab, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

Abstract

Dedifferentiated carcinoma of the female genital tract is a relatively recently recognized aggressive tumor affecting predominantly perimenopausal and postmenopausal women. In addition to having an undifferentiated component, dedifferentiated carcinoma includes a juxtaposed endometrioid adenocarcinoma, FIGO grade 1 or 2. Molecular characterization of these tumors has been a subject of discussion in multiple recent articles. We present a case of dedifferentiated carcinoma of the ovary in a 70-year-old female demonstrating concurrent inactivation of ARID1A and ARID1B. To the best of our knowledge, this is the second clinical report demonstrating dedifferentiated carcinoma of the ovary with concurrent inactivation of ARID1A and ARID1B. ARID1A and ARID1B inactivation seems to represent an alternate mechanism of switch/sucrose nonfermentable complex inactivation in the development of dedifferentiated carcinoma. Additional studies are warranted to precisely understand the molecular mechanism of cellular dedifferentiation in the dedifferentiated endometrial/ovarian carcinomas, thus guiding the development of targeted therapy.

Publisher

SAGE Publications

Subject

Pathology and Forensic Medicine,Surgery,Anatomy

Link

http://journals.sagepub.com/doi/pdf/10.1177/10668969231157776

Reference23 articles.

1. Endometrial and ovarian carcinomas with undifferentiated components: clinically aggressive and frequently underrecognized neoplasms

2. Concurrent ARID1A and ARID1B inactivation in endometrial and ovarian dedifferentiated carcinomas

3. Association of Low-Grade Endometrioid Carcinoma of the Uterus and Ovary With Undifferentiated Carcinoma: A New Type of Dedifferentiated Carcinoma?

4. Dedifferentiated endometrial carcinoma: A report of three cases and review of the literature

5. Dedifferentiated endometrioid adenocarcinoma of the uterus: A case series and review of literature