<i>RAF1-</i>rearranged Spindle Cell Mesenchymal Tumor With Calcification and Heterotopic Ossification: A Case Report and Review of Literature-Reference-Cited by-同舟云学术

RAF1-rearranged Spindle Cell Mesenchymal Tumor With Calcification and Heterotopic Ossification: A Case Report and Review of Literature

Published:2023-05-04 Issue:1 Volume:32 Page:133-139
ISSN:1066-8969
Container-title:International Journal of Surgical Pathology
language:en
Short-container-title:Int J Surg Pathol

Author:

Cordier Fleur¹^ORCID,Loontiens Siebe²³⁴,Van der Meulen Joni²³⁴,Lapeire Lore²⁵,van Ramshorst Gabrielle H.⁶⁷,Sys Gwen²⁸,Van Dorpe Jo¹²,Creytens David¹²^ORCID

Affiliation:

1. Department of Pathology, Ghent University Hospital, Ghent University, Ghent, Belgium

2. CRIG, Cancer Research Institute Ghent, Ghent University Hospital, Ghent University, Ghent, Belgium

3. Molecular Diagnostics Ghent University Hospital (MDG), Ghent University Hospital, Ghent University, Ghent, Belgium

4. Department of Biomolecular Medicine, Ghent University, Ghent, Belgium

5. Department of Medical Oncology, Ghent University Hospital, Ghent University, Ghent, Belgium

6. Department of Gastrointestinal Surgery, Ghent University Hospital, Ghent University, Ghent, Belgium

7. Department of Human Structure and Repair, Ghent University, Ghent, Belgium

8. Department of Traumatology and Orthopaedics, Ghent University Hospital, Ghent University, Ghent, Belgium

Abstract

We report an exceptional case of a spindle cell mesenchymal tumor with S100 and CD34 co-reactivity, which harbored a SLMAP::RAF1 fusion. To the best of our knowledge, this is the second case of a spindle cell mesenchymal tumor with S100 and CD34 co-reactivity with this specific fusion. Remarkable is the presence of calcification and heterotopic ossification in the center of our lesion, a feature that, to our knowledge, has not been described yet in RAF1-rearranged spindle cell mesenchymal tumors.

Publisher

SAGE Publications

Subject

Pathology and Forensic Medicine,Surgery,Anatomy

Link

http://journals.sagepub.com/doi/pdf/10.1177/10668969231167493

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3. A novel group of spindle cell tumors defined by S100 and CD34 co-expression shows recurrent fusions involving RAF1, BRAF, and NTRK1/2 genes

4. RAF1-rearranged spindle cell tumour: report of two additional cases with identification of a novel FMR1-RAF1 fusion

5. Spindle Cell Tumors With RET Gene Fusions Exhibit a Morphologic Spectrum Akin to Tumors With NTRK Gene Fusions

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