Early-Onset EBV-Positive Post-transplant Plasmablastic Lymphoma Arising in a Liver Allograft

Author:

Benítez Carlos E.1,Rey Paula1,Zoroquiaín Pablo2,Martínez Jorge3,Ramírez Pablo4,Arrese Marco1,Pérez-Ayuso Rosa María1,Valbuena José R.2

Affiliation:

1. Departments of Gastroenterology, Facultad de Medicina Pontificia Universidad Católica de Chile, Santiago, Chile

2. Anatomic Pathology, Facultad de Medicina Pontificia Universidad Católica de Chile, Santiago de Chile, Chile

3. Hepatobiliary Surgery, Facultad de Medicina Pontificia Universidad Católica de Chile, Santiago de Chile, Chile

4. Hematology-Oncology, Facultad de Medicina Pontificia Universidad Católica de Chile, Santiago de Chile, Chile

Abstract

We report a case of a 51-year-old man who received a cadaveric liver allograft for autoimmune and hepatopulmonary syndrome. The patient was admitted with symptoms of progressive vomiting and diarrhea 16 months after transplantation. Laboratory studies showed abnormal liver functions, and abdominal magnetic resonance imaging (MRI) showed a 76-mm heterogeneous mass in the liver. Histological examination showed a malignant lymphoid neoplasm with plasmablastic features. Plasmablastic lymphoma (PL) is rare in the post-transplantation period. To the best of our knowledge, only 25 well-documented cases of posttransplant PL, including ours, have been described.

Publisher

SAGE Publications

Subject

Pathology and Forensic Medicine,Surgery,Anatomy

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