A Case of Poorly Differentiated Synovial Sarcoma Arising in a Nasal Cavity Radiation Field: An Unusual Tumor in an Unusual Location

Author:

Jobbagy Soma12,Bilek Melissa3ORCID,You Bei3,Shah Maya4,Jobbagy Zsolt3ORCID

Affiliation:

1. Department of Pathology, Massachusetts General Hospital, Boston, MA, USA

2. Department of Pathology, Harvard Medical School, Boston, MA, USA

3. Department of Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA

4. Division of Hematology and Oncology, Newark Beth Israel Medical Center, Newark, NJ, USA

Abstract

Synovial sarcomas are high-grade soft tissue sarcomas of primitive mesenchymal origin which are defined by a pathognomonic t(X;18)(p11,q11) translocation, and which occur in pediatric and adult populations. Herein we report a case of a 33-year-old female with a history of nasopharyngeal carcinoma status post radiotherapy, presenting with a poorly differentiated synovial sarcoma of the nasal cavity arising in the radiation field. While the development of radiation-associated sarcoma is a known complication of radiotherapy, to date only 10 cases of synovial sarcoma have been reported to occur in previously irradiated tissues. Moreover, only 1 case of poorly differentiated synovial sarcoma involving the nasopharynx has been described.

Publisher

SAGE Publications

Subject

Pathology and Forensic Medicine,Surgery,Anatomy

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Pathology, Genetics, and Molecular Biology;Imaging of Synovial Tumors and Tumor-like Conditions;2023

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