Cecal Adenocarcinoma With Prominent Rhabdoid Feature: Report of a Case With Immunohistochemical, Ultrastructural, and Molecular Analyses

Author:

Kono Tokuyuki1,Imai Yasuo2,Imura Johji3,Ono Yuko1,Hagiwara Shingo4,Taira Katsuyoshi4,Fujita Masanori4,Tsubaki Masahiro4,Sunagawa Masakatsu4,Fujimori Takahiro1

Affiliation:

1. Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine, Tochigi, Japan

2. Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine, Tochigi, Japan,

3. Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine, Tochigi, Japan, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan

4. First Department of Surgery Dokkyo Medical University School of Medicine, Tochigi, Japan

Abstract

Colorectal adenocarcinoma with rhabdoid phenotype is extremely rare, and only 1 case of adenocarcinoma showing rhabdoid dedifferentiation has been reported. The authors present another case of cecal adenocarcinoma with prominent rhabdoid feature in a 66-year-old man. The 13-cm sized tumor consisted mainly of rhabdoid cells and partly of adenocarcinoma, and transition from adenocarcinoma to rhabdoid areas was noted. Ultrastructural analysis revealed intracytoplasmic aggregates of intermediate filaments in the rhabdoid cells. Adenocarcinoma cells were diffusely immunoreactive to cytokeratin 7 and AE1/3, but occasionally positive for vimentin. The rhabdoid cells were negative for cytokeratin 7, weakly/focally immunoreactive to AE1/3, and diffusely positive for vimentin. These results suggested that the rhabdoid cells were dedifferentiated adenocarcinoma. Analysis of the rhabdoid cells with molecular techniques is also presented.

Publisher

SAGE Publications

Subject

Pathology and Forensic Medicine,Surgery,Anatomy

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